Apresentação - Volume 5 Nº 1

Cover Vol.5 No.1, February 2008

CNS Drug Reviews, Volume 5, No. 1, Spring 1999

Glutamate receptors can be broadly classified into two subtypes: ionotropic glutamate receptors, which are ligand-gated ion channels, and metabotropic glutamate receptors (mGlu receptors), which are coupled via G proteins to second messenger systems (32). When activated, ionotropic glutamate receptors produce an influx of cations into the cell, directly depolarizing the postsynaptic neuron and ...

CNS Drug Reviews, Volume 5, No. 1, Spring 1999

Historically, the products of Cannabis sativa (or marijuana) have been used in socioreligious rites and for medicinal and recreational purposes. Multiple medical purposes, related or not to religious rituals, were prevalent in the ancient world (Assyria, Egypt, Rome, Greece and China) and India (54). Marijuana was used less widely in Western Europe and North America (54,55). Because reliable cl...

CNS Drug Reviews, Volume 5, No. 1, Spring 1999

In the past ten years, the brain’s status as “immune privileged,” that is, beyond the surveillance and influence of the immune system, has been reconsidered as important interactions between the nervous and immune systems have been recognized. Increasing attention is being paid to the role of inflammatory responses in degenerative diseases of the brain, particularly in Aizheimer’s disease, as w...

CNS Drug Reviews, Volume 5, No. 1, Spring 1999

In commemoration of Aaron Lerner’s isolation and chemical identification of the indoleamine hormone N-acetyl-5-methoxytryptamine (better known as melatonin) the Institute for Hormone and Fertility Research at the University of Hamburg called together melatonin researchers, both established and newcomers, to discuss this interesting molecule and its impact on basic and clinical research. In addi...